Erratum to: Extrapyramidal symptoms after exposure to calcium channel blocker-flunarizine or cinnarizine
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چکیده
منابع مشابه
Pharmacological Profile of Flunarizine: a Calcium Channel Blocker
Flunarizine is a non selective calcium channel antagonist. It is highly lipophilic compound which distributes preferentially in adipose tissue and passes the blood brain barrier readily. Numerous preclinical and controlled clinical studies, including double blind clinical studies in which the drug was compared with placebo or standard drugs in particular disease showing efficacy in migraine, ve...
متن کاملEffects of the topically applied calcium-channel blocker flunarizine on intraocular pressure in clinically normal dogs.
OBJECTIVE To determine effects of the topically applied calcium-channel blocker flunarizine on intraocular pressure (IOP) in clinically normal dogs. ANIMALS 20 dogs. PROCEDURES Baseline diurnal IOPs were determined by use of a rebound tonometer on 2 consecutive days. Subsequently, 1 randomly chosen eye of each dog was treated topically twice daily for 5 days with 0.5% flunarizine. During th...
متن کاملEvaluation of Mutagenicity of Mebudipine, a New Calcium Channel Blocker
Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
متن کاملCalcium-Channel Blocker Overdose
1522-8401/$ see fro doi:10.1016/j.cpem.2 Department of Eme Children’s Hospit RI 02903, USA. Reprint requests and Department of E Children’s Hospit RI 02903, USA. Calcium-channel blockers (CCB) were first developed in the 1960s. Since then, the list of formulations and variety of uses has increased significantly. Unfortunately, toxic exposures to CCBs have also increased since their debut. This ...
متن کاملEvaluation of Mutagenicity of Mebudipine, a New Calcium Channel Blocker
Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
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ژورنال
عنوان ژورنال: European Journal of Clinical Pharmacology
سال: 2017
ISSN: 0031-6970,1432-1041
DOI: 10.1007/s00228-017-2268-5